1.鍎€鍣ㄧ啊(ji菐n)浠�
TIC-600鏄ぉ鐟炲剙鍣ㄧ簿蹇冪爺鐧�(f膩)鐨勫叏濉戝寲閫氱敤鍨�銆佽嚜鍐嶇敓鎶戝埗妯″紡鐨勯洟瀛愯壊璀滃剙锛屽彲鐢ㄤ簬妾㈡脯(c猫)甯歌(gu墨)鐒�(w煤)姗�(j墨)闄伴櫧(y谩ng)闆㈠瓙銆侀2鐢ㄦ按娑堟瘨鍓敘(ch菐n)鐗�銆佹捍閰搁菇銆佹湁姗�(j墨)閰�銆佽兒绛�锛屼笉鍍呮搧鏈夊唬娉�銆佸畬鍠勩€佸厛閫�(j矛n)鐨勬噳(y墨ng)鐢ㄨВ姹鸿兘鍔�锛屽悓鏅�(sh铆)鐐虹敤鎴�(h霉)甯朵締(l谩i)鑷嫊(d貌ng)鍖栥€佷汉鎬у寲鐨勫剙鍣ㄦ噳(y墨ng)鐢ㄩ珨椹�(y脿n)锛屽彲寤f硾鎳�(y墨ng)鐢ㄤ簬鐠�(hu谩n)澧�銆侀鍝�銆佸寲宸ャ€佽静(n贸ng)妤�(y猫)銆佺う鐢�(ch菐n)銆侀浕瀛愰浕鍣ㄧ瓑琛屾キ(y猫)涓父閲忓強寰棔閲忛洟瀛愮殑妾㈡脯(c猫)鍒嗘瀽銆�
鍦�1. TIC-600闆㈠瓙鑹茶瓬鍎€澶栬鍦�
2.妾㈡脯(c猫)鐓欒崏涓隘鍚噺
鐓欒崏涓隘鍚噺楂樹綆鏄⿻(p铆ng)瀹氱厵鑽夊搧璩�(zh矛)鐨勪竴鍊�(g猫)閲嶈鎸囨(bi膩o)銆傜厵钁変腑鍚湁0.3-0.6%鐨勬隘姣旇純鐞嗘兂锛岀厵钁夎唱(zh矛)鍦版煍杌�锛屽叿鏈夊綀鎬у拰娌规饯(r霉n)锛岃啫鑴规€уソ锛岀牬纰庣巼浣庯紱鍚隘浣庝簬0.3%鏅�(sh铆)锛岀厵钁夊共鐕ョ矖绯�锛屾槗鐮寸锛屽垏绲茬巼浣�锛涘惈姘噺鍦�0.6%浠ヤ笂鏅�(sh铆)锛岃唱(zh矛)閲忔槑椤笅闄�锛岀厵钁夐鑹查洔鑹叉枒椐佹垨榛贰鐒�(w煤)鍏夛紝闆e劜(ch菙)瀛�锛屾槗鐧�(f膩)闇�锛岀噧鐕掓€у樊銆�
鐓欒崏涓隘鍚噺鐨勬脯(c猫)瀹�锛屼竴鐩村欢鐢ㄥ偝绲�(t菕ng)鐨勫寲瀛�(xu茅)鍒嗘瀽鏂规硶锛屽鑾埦鍒嗘瀽娉�銆佹瘮鑹插垎鏋愭硶锛屼絾閫欎簺鏂规硶鎿嶄綔绻佺懀锛岄渶瑕佸绋寲瀛�(xu茅)瑭﹀姂锛屼笖闈堟晱搴︿綆锛屾槗鍙楀共鎿�銆傞洟瀛愯壊璀滄硶鏄柊鐧�(f膩)灞曡捣渚�(l谩i)鐨勮壊璀滃垎鏋愭柟娉曪紝鍏锋湁闈堟晱搴﹂珮銆佸垎鏋愰€熷害蹇�銆佽│鍔戠敤閲忓皯鐨勭壒榛�(di菐n)銆傛湰鏂囬噰鐢ㄩ洟瀛愯壊璀滄硶娓�(c猫)瀹氱厵鑽変腑姘惈閲�锛屾晥鏋滅悊鎯筹紝鍙帹寤f噳(y墨ng)鐢ㄤ簬鐓欒崏琛屾キ(y猫)涓隘鍚噺鐨勬脯(c猫)瀹�銆�
3.瀵�(sh铆)椹�(y脿n)閮ㄥ垎
3.1 瑭﹀姂鍙婂剙鍣�
娣嬫礂娑诧細纰抽吀姘垑[C(NaHCO3)=8mmol/l]-纰抽吀閳�[C(Na2CO3)=4.0mmol/l]锛氾紙鍦�(gu贸)钘ラ泦鍦�(tu谩n)鍖栧(xu茅)瑭﹀姂鏈夐檺鍏徃锛�
姘洟瀛愭(bi膩o)娑诧紙1000渭g/ml锛夛紙鍦�(gu贸)瀹舵(bi膩o)婧�(zh菙n)鐗╄唱(zh矛)涓績锛�
闆㈠瓙鑹茶瓬鍎€锛�TIC-600锛屾睙铇囧ぉ鐟炲剙鍣ㄨ偂浠芥湁闄愬叕鍙革級
瓒呰伈娉㈡竻娲楀剙锛堟槅灞辫秴鑱插剙鍣ㄦ湁闄愬叕鍙革級
BS 224S闆诲瓙澶╁钩锛堣辰澶氬埄鏂瀛�(xu茅)鍎€鍣紙鍖椾含锛夋湁闄愬叕鍙�锛�0.1mg锛�
SHZ-D鍨嬪惊鐠�(hu谩n)姘村紡鐪熺┖娉碉紙闉忕京甯備簣鑿剙鍣ㄦ湁闄愬叕鍙革級
绉绘恫妲�?zhu膩n)菛鑱�?gu贸)鏅槶寰�锛�10-100uL銆�100-1000uL锛�
0.22渭m寰瓟婵捐啘锛堜笂娴峰畨璀滐級
婧跺姂鎶芥烤瑁濈疆锛堟触楱板(sh铆)椹�(y脿n)瑷�(sh猫)鍌欐湁闄愬叕鍙革級
瓒呯磾姘存(j墨)锛�A-10瓒呯磾姘存(j墨)锛岀編鍦�(gu贸)瀵嗙悊鍗氾級
3.2 瀵�(sh铆)椹�(y脿n)閬�(gu貌)绋�
3.2.1 妯e搧闋�(y霉)铏曠悊锛�
婧�(zh菙n)纰虹ū(ch膿ng)閲忕厵鑽夋ǎ鍝� 0.5g 锛堢簿纰哄埌0.1mg锛夎嚦閷愬舰鐡朵腑锛屽姞鍏�100ml瓒呯磾姘磋秴鑱叉彁鍙�30min锛涜秴鑱插畬鎴愬悗锛屽彇閮ㄥ垎妯e搧涓婃竻娑查洟蹇冿紙杞�(zhu菐n)閫�6000r/min闆㈠績15min锛�銆傞洟蹇冨畬鎴愬悗锛屽彇涓婃竻娑茬█閲�20鍊嶅苟浠�0.22渭m寰瓟婵捐啘閬�(gu貌)婵�銆傛ǎ鍝佺稉(j墨ng)闋�(y霉)铏曠悊鍚庢敞鍏ラ洟瀛愯壊璀滃剙閫�(j矛n)妯g郴绲�(t菕ng)锛岃閷勫嘲楂樻垨宄伴潰绌嶃€�
3.2.2 鍎€鍣ㄥ弮鏁�(sh霉)
灏囬厤缃ソ鐨勬穻娲楁恫閬�(gu貌)0.22渭m寰瓟婵捐啘鎶芥烤锛屽啀缍�(j墨ng)瓒呰伈娉㈣劔姘�10min锛屽苟鍎�(y艒u)鍖栧剙鍣ㄥ伐浣滃弮鏁�(sh霉)锛屼娇鍎€鍣ㄧ┅(w臎n)瀹氭€ч仈(d谩)鍒版渶浣筹紝鍏烽珨宸ヤ綔鍙冩暩(sh霉)瑕�(ji脿n)琛�1锛屽湪鍎€鍣ㄦ渶浣冲伐浣滃弮鏁�(sh霉)姊濅欢涓�锛屽皪(du矛)姘磋唱(zh矛)妯e搧閫�(j矛n)琛屾脯(c猫)瑭�銆�
琛�1.鍎€鍣ㄥ伐浣滃弮鏁�(sh霉)
宸ヤ綔鍙冩暩(sh霉)
|
瑷�(sh猫)瀹氬€�
|
娣嬫礂娑叉祦閲�/L/min
|
1.5
|
鑹茶瓬鏌辨韩搴�/鈩�
|
30
|
妾㈡脯(c猫)鍣ㄦ韩搴�/鈩�
|
35
|
鎶戝埗鍣ㄩ浕娴�/mA
|
50
|
瀹氶噺鐠�(hu谩n)/渭l
|
25
|
3.2.3 妯�(bi膩o)娑查厤鍒�
鍒嗗垾绉诲彇涓€瀹氶噺Cl-妯�(bi膩o)娑诧紙1000渭g/ml锛夎嚦100ml鐜荤拑瀹归噺鐡�锛岄厤缃垚婵冨害濡備笅琛�2鎵€绀虹郴鍒楁(bi膩o)娑层€�
琛�2. Cl-闆㈠瓙妯�(bi膩o)娑叉績搴�
闄伴洟瀛�
|
妯�(bi膩o)娑叉績搴︼紙渭g/ml锛�
|
Std1
|
Std2
|
Std3
|
Std4
|
Cl-
|
1
|
2
|
5
|
10
|
鍦�2. Cl-闆㈠瓙妯�(bi膩o)婧�(zh菙n)鏇茬窔(xi脿n)鍦�
3.3瀵�(sh铆)椹�(y脿n)鏁�(sh霉)鎿�(j霉)
3.3.1 妯e搧鍔犳(bi膩o)鍥炴敹鐜�
灏囧叐浠界厵鑽夋ǎ鍝佸垎鍒ュ姞妯�(bi膩o)涓嶅悓婵冨害Cl-闆㈠瓙鍚庨€�(j矛n)琛岄爯(y霉)铏曠悊锛岀劧鍚庡皣姣忎唤妯e搧鐨勬ǎ鍝佹憾娑查€�(j矛n)妯f脯(c猫)瀹氾紝鏍规摎(j霉)娓�(c猫)瑭︾祼(ji茅)鏋滆▓(j矛)绠楀姞妯�(bi膩o)鍥炴敹鐜囷紝瑭崇窗(x矛)鏁�(sh霉)鎿�(j霉)瑕�(ji脿n)琛�3銆�
琛�3.鐓欒崏妯e搧鍔犳(bi膩o)鍥炴敹鐜囨暩(sh霉)鎿�(j霉)
闄伴洟瀛�
Cl-
|
娓�(c猫)瑭︾祼(ji茅)鏋�/渭g/ml
|
鐓欒崏1#
|
鍔犳(bi膩o)0.2 渭g/ml
|
鍥炴敹鐜�/%
|
鍔犳(bi膩o)0.5渭g/ml
|
鍥炴敹鐜�/%
|
鍔犳(bi膩o)1.0渭g/ml
|
鍥炴敹鐜�/%
|
0.825
|
1.028
|
101.5
|
1.315
|
98.0
|
1.850
|
102.5
|
鐓欒崏2#
|
鍔犳(bi膩o)0.2 渭g/ml
|
鍥炴敹鐜�/%
|
鍔犳(bi膩o)0.5渭g/ml
|
鍥炴敹鐜�/%
|
鍔犳(bi膩o)1.0渭g/ml
|
鍥炴敹鐜�/%
|
1.225
|
1.430
|
102.5
|
1.702
|
95.4
|
2.197
|
97.2
|
3.4绲�(ji茅)璜�
鐢卞(sh铆)椹�(y脿n)鍙煡锛岄洟瀛愯壊璀滃剙TIC-600娓�(c猫)瑭︾厵鑽変腑姘惈閲忥紝婧�(zh菙n)纰哄害楂�锛屾渶灏忔鍑烘績搴︿綆锛屾柟娉曠啊(ji菐n)鍠揩鎹�锛屽畬鍏ㄦ豢(m菐n)瓒崇厵鑽夎妤�(y猫)灏�(du矛)浜庣厵鑽変腑姘惈閲忔娓�(c猫)鐨勯渶姹�銆�
4 鍙冭€冩枃鐛�(xi脿n)
[1]鑻荤辜绱�锛岃В鎴愬枩锛屽嫉楹楅潨銆傞洟瀛愯壊璀滄硶娓�(c猫)瀹氶夯榛冧腑鐨勭劇(w煤)姗�(j墨)闄伴洟瀛� [J]锛岃壊璀�锛�2004,22锛�1锛�:72
[2]鐗熶笘鑺�锛屽妷鍏嬬磵锛屼竵鏇夐潨銆傞洟瀛愯壊璀滄柟娉曟(j墨)鎳�(y墨ng)鐢�銆傚寳浜細鍖栧(xu茅)宸ユキ(y猫)鍑虹増绀�锛�2000.64